specialisation

Macrophages, Cardiovascular Disease, Atherosclerosis, Epigenetics

Research interests

In our lab we study macrophage epigenetic processes in cardiovascular disease with a focus on atherosclerosis. Epigenetic processes are critical regulators of the immune system and are emerging as targets for diagnosis and interventions. Also in monocytes and macrophages epigenetic pathways are important in regulating responses and cellular phenotype and thereby impact on disease development.

I am highly interested in the the Polycomb Repressive Complex 2 (PRC2) in macrophages and atherosclerosis and my work integrates fundamental research questions with translational applications both in vitro and in vivo.

Research output

  1. Myeloid Ezh2 Deficiency Limits Atherosclerosis Development

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Targeting epigenetics as atherosclerosis treatment: an updated view

    Research output: Contribution to journalArticleAcademicpeer-review

  3. PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Myeloid Kdm6b deficiency results in advanced atherosclerosis

    Research output: Contribution to journalArticleAcademicpeer-review

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